Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial.
Identifieur interne : 000395 ( Main/Exploration ); précédent : 000394; suivant : 000396Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial.
Auteurs : Kayvon Modjarrad [États-Unis] ; Christine C. Roberts [Corée du Sud] ; Kristin T. Mills [États-Unis] ; Amy R. Castellano [États-Unis] ; Kristopher Paolino [États-Unis] ; Kar Muthumani [États-Unis] ; Emma L. Reuschel [États-Unis] ; Merlin L. Robb [États-Unis] ; Trina Racine [Canada] ; Myoung-Don Oh [Corée du Sud] ; Claude Lamarre [Canada] ; Faraz I. Zaidi [États-Unis] ; Jean Boyer [États-Unis] ; Sagar B. Kudchodkar [Corée du Sud] ; Moonsup Jeong [Corée du Sud] ; Janice M. Darden [États-Unis] ; Young K. Park [Corée du Sud] ; Paul T. Scott [États-Unis] ; Celine Remigio [Corée du Sud] ; Ajay P. Parikh [États-Unis] ; Megan C. Wise [États-Unis] ; Ami Patel [États-Unis] ; Elizabeth K. Duperret [États-Unis] ; Kevin Y. Kim [États-Unis] ; Hyeree Choi [États-Unis] ; Scott White [États-Unis] ; Mark Bagarazzi [États-Unis] ; Jeanine M. May [États-Unis] ; Deborah Kane [Corée du Sud] ; Hyojin Lee [Corée du Sud] ; Gary Kobinger [Canada] ; Nelson L. Michael [États-Unis] ; David B. Weiner [États-Unis] ; Stephen J. Thomas [États-Unis] ; Joel N. Maslow [Corée du Sud]Source :
- The Lancet. Infectious diseases [ 1474-4457 ] ; 2019.
Abstract
Middle East respiratory syndrome (MERS) coronavirus causes a highly fatal lower-respiratory tract infection. There are as yet no licensed MERS vaccines or therapeutics. This study (WRAIR-2274) assessed the safety, tolerability, and immunogenicity of the GLS-5300 MERS coronavirus DNA vaccine in healthy adults.
DOI: 10.1016/S1473-3099(19)30266-X
PubMed: 31351922
Affiliations:
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Roberts</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea. Electronic address: croberts@geneonels-us.com.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Mills, Kristin T" sort="Mills, Kristin T" uniqKey="Mills K" first="Kristin T" last="Mills">Kristin T. 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Reuschel</name><affiliation wicri:level="2"><nlm:affiliation>Wistar Institute, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Robb, Merlin L" sort="Robb, Merlin L" uniqKey="Robb M" first="Merlin L" last="Robb">Merlin L. Robb</name><affiliation wicri:level="2"><nlm:affiliation>Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Racine, Trina" sort="Racine, Trina" uniqKey="Racine T" first="Trina" last="Racine">Trina Racine</name><affiliation wicri:level="1"><nlm:affiliation>Université Laval, Quebec City, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Université Laval, Quebec City, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><affiliation wicri:level="3"><nlm:affiliation>Seoul National University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lamarre, Claude" sort="Lamarre, Claude" uniqKey="Lamarre C" first="Claude" last="Lamarre">Claude Lamarre</name><affiliation wicri:level="1"><nlm:affiliation>Université Laval, Quebec City, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Université Laval, Quebec City, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Zaidi, Faraz I" sort="Zaidi, Faraz I" uniqKey="Zaidi F" first="Faraz I" last="Zaidi">Faraz I. Zaidi</name><affiliation wicri:level="2"><nlm:affiliation>Wistar Institute, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Boyer, Jean" sort="Boyer, Jean" uniqKey="Boyer J" first="Jean" last="Boyer">Jean Boyer</name><affiliation wicri:level="2"><nlm:affiliation>Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inovio Pharmaceuticals, Plymouth Meeting, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kudchodkar, Sagar B" sort="Kudchodkar, Sagar B" uniqKey="Kudchodkar S" first="Sagar B" last="Kudchodkar">Sagar B. Kudchodkar</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Moonsup" sort="Jeong, Moonsup" uniqKey="Jeong M" first="Moonsup" last="Jeong">Moonsup Jeong</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Darden, Janice M" sort="Darden, Janice M" uniqKey="Darden J" first="Janice M" last="Darden">Janice M. Darden</name><affiliation wicri:level="2"><nlm:affiliation>Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Park, Young K" sort="Park, Young K" uniqKey="Park Y" first="Young K" last="Park">Young K. Park</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Scott, Paul T" sort="Scott, Paul T" uniqKey="Scott P" first="Paul T" last="Scott">Paul T. Scott</name><affiliation wicri:level="2"><nlm:affiliation>Walter Reed Army Institute for Research, Silver Spring, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Walter Reed Army Institute for Research, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Remigio, Celine" sort="Remigio, Celine" uniqKey="Remigio C" first="Celine" last="Remigio">Celine Remigio</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Parikh, Ajay P" sort="Parikh, Ajay P" uniqKey="Parikh A" first="Ajay P" last="Parikh">Ajay P. Parikh</name><affiliation wicri:level="2"><nlm:affiliation>Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wise, Megan C" sort="Wise, Megan C" uniqKey="Wise M" first="Megan C" last="Wise">Megan C. Wise</name><affiliation wicri:level="2"><nlm:affiliation>Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inovio Pharmaceuticals, Plymouth Meeting, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Patel, Ami" sort="Patel, Ami" uniqKey="Patel A" first="Ami" last="Patel">Ami Patel</name><affiliation wicri:level="2"><nlm:affiliation>Wistar Institute, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Duperret, Elizabeth K" sort="Duperret, Elizabeth K" uniqKey="Duperret E" first="Elizabeth K" last="Duperret">Elizabeth K. Duperret</name><affiliation wicri:level="2"><nlm:affiliation>Wistar Institute, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kim, Kevin Y" sort="Kim, Kevin Y" uniqKey="Kim K" first="Kevin Y" last="Kim">Kevin Y. Kim</name><affiliation wicri:level="2"><nlm:affiliation>Wistar Institute, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Choi, Hyeree" sort="Choi, Hyeree" uniqKey="Choi H" first="Hyeree" last="Choi">Hyeree Choi</name><affiliation wicri:level="2"><nlm:affiliation>Wistar Institute, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="White, Scott" sort="White, Scott" uniqKey="White S" first="Scott" last="White">Scott White</name><affiliation wicri:level="2"><nlm:affiliation>Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inovio Pharmaceuticals, Plymouth Meeting, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bagarazzi, Mark" sort="Bagarazzi, Mark" uniqKey="Bagarazzi M" first="Mark" last="Bagarazzi">Mark Bagarazzi</name><affiliation wicri:level="2"><nlm:affiliation>Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inovio Pharmaceuticals, Plymouth Meeting, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="May, Jeanine M" sort="May, Jeanine M" uniqKey="May J" first="Jeanine M" last="May">Jeanine M. May</name><affiliation wicri:level="2"><nlm:affiliation>Emmes Corporation, Rockville, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emmes Corporation, Rockville, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kane, Deborah" sort="Kane, Deborah" uniqKey="Kane D" first="Deborah" last="Kane">Deborah Kane</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyojin" sort="Lee, Hyojin" uniqKey="Lee H" first="Hyojin" last="Lee">Hyojin Lee</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kobinger, Gary" sort="Kobinger, Gary" uniqKey="Kobinger G" first="Gary" last="Kobinger">Gary Kobinger</name><affiliation wicri:level="1"><nlm:affiliation>Université Laval, Quebec City, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Université Laval, Quebec City, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Michael, Nelson L" sort="Michael, Nelson L" uniqKey="Michael N" first="Nelson L" last="Michael">Nelson L. Michael</name><affiliation wicri:level="2"><nlm:affiliation>Walter Reed Army Institute for Research, Silver Spring, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Walter Reed Army Institute for Research, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Weiner, David B" sort="Weiner, David B" uniqKey="Weiner D" first="David B" last="Weiner">David B. Weiner</name><affiliation wicri:level="2"><nlm:affiliation>Wistar Institute, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Thomas, Stephen J" sort="Thomas, Stephen J" uniqKey="Thomas S" first="Stephen J" last="Thomas">Stephen J. Thomas</name><affiliation wicri:level="2"><nlm:affiliation>Walter Reed Army Institute for Research, Silver Spring, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Walter Reed Army Institute for Research, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Maslow, Joel N" sort="Maslow, Joel N" uniqKey="Maslow J" first="Joel N" last="Maslow">Joel N. Maslow</name><affiliation wicri:level="3"><nlm:affiliation>GeneOne Life Science, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>GeneOne Life Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Infectious diseases</title><idno type="eISSN">1474-4457</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) coronavirus causes a highly fatal lower-respiratory tract infection. There are as yet no licensed MERS vaccines or therapeutics. This study (WRAIR-2274) assessed the safety, tolerability, and immunogenicity of the GLS-5300 MERS coronavirus DNA vaccine in healthy adults.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Maryland</li><li>Pennsylvanie</li><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Modjarrad, Kayvon" sort="Modjarrad, Kayvon" uniqKey="Modjarrad K" first="Kayvon" last="Modjarrad">Kayvon Modjarrad</name></region><name sortKey="Bagarazzi, Mark" sort="Bagarazzi, Mark" uniqKey="Bagarazzi M" first="Mark" last="Bagarazzi">Mark Bagarazzi</name><name sortKey="Boyer, Jean" sort="Boyer, Jean" uniqKey="Boyer J" first="Jean" last="Boyer">Jean Boyer</name><name sortKey="Castellano, Amy R" sort="Castellano, Amy R" uniqKey="Castellano A" first="Amy R" last="Castellano">Amy R. Castellano</name><name sortKey="Choi, Hyeree" sort="Choi, Hyeree" uniqKey="Choi H" first="Hyeree" last="Choi">Hyeree Choi</name><name sortKey="Darden, Janice M" sort="Darden, Janice M" uniqKey="Darden J" first="Janice M" last="Darden">Janice M. Darden</name><name sortKey="Duperret, Elizabeth K" sort="Duperret, Elizabeth K" uniqKey="Duperret E" first="Elizabeth K" last="Duperret">Elizabeth K. Duperret</name><name sortKey="Kim, Kevin Y" sort="Kim, Kevin Y" uniqKey="Kim K" first="Kevin Y" last="Kim">Kevin Y. Kim</name><name sortKey="May, Jeanine M" sort="May, Jeanine M" uniqKey="May J" first="Jeanine M" last="May">Jeanine M. May</name><name sortKey="Michael, Nelson L" sort="Michael, Nelson L" uniqKey="Michael N" first="Nelson L" last="Michael">Nelson L. Michael</name><name sortKey="Mills, Kristin T" sort="Mills, Kristin T" uniqKey="Mills K" first="Kristin T" last="Mills">Kristin T. Mills</name><name sortKey="Muthumani, Kar" sort="Muthumani, Kar" uniqKey="Muthumani K" first="Kar" last="Muthumani">Kar Muthumani</name><name sortKey="Paolino, Kristopher" sort="Paolino, Kristopher" uniqKey="Paolino K" first="Kristopher" last="Paolino">Kristopher Paolino</name><name sortKey="Parikh, Ajay P" sort="Parikh, Ajay P" uniqKey="Parikh A" first="Ajay P" last="Parikh">Ajay P. Parikh</name><name sortKey="Patel, Ami" sort="Patel, Ami" uniqKey="Patel A" first="Ami" last="Patel">Ami Patel</name><name sortKey="Reuschel, Emma L" sort="Reuschel, Emma L" uniqKey="Reuschel E" first="Emma L" last="Reuschel">Emma L. Reuschel</name><name sortKey="Robb, Merlin L" sort="Robb, Merlin L" uniqKey="Robb M" first="Merlin L" last="Robb">Merlin L. Robb</name><name sortKey="Scott, Paul T" sort="Scott, Paul T" uniqKey="Scott P" first="Paul T" last="Scott">Paul T. Scott</name><name sortKey="Thomas, Stephen J" sort="Thomas, Stephen J" uniqKey="Thomas S" first="Stephen J" last="Thomas">Stephen J. Thomas</name><name sortKey="Weiner, David B" sort="Weiner, David B" uniqKey="Weiner D" first="David B" last="Weiner">David B. Weiner</name><name sortKey="White, Scott" sort="White, Scott" uniqKey="White S" first="Scott" last="White">Scott White</name><name sortKey="Wise, Megan C" sort="Wise, Megan C" uniqKey="Wise M" first="Megan C" last="Wise">Megan C. Wise</name><name sortKey="Zaidi, Faraz I" sort="Zaidi, Faraz I" uniqKey="Zaidi F" first="Faraz I" last="Zaidi">Faraz I. Zaidi</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Roberts, Christine C" sort="Roberts, Christine C" uniqKey="Roberts C" first="Christine C" last="Roberts">Christine C. Roberts</name></region><name sortKey="Jeong, Moonsup" sort="Jeong, Moonsup" uniqKey="Jeong M" first="Moonsup" last="Jeong">Moonsup Jeong</name><name sortKey="Kane, Deborah" sort="Kane, Deborah" uniqKey="Kane D" first="Deborah" last="Kane">Deborah Kane</name><name sortKey="Kudchodkar, Sagar B" sort="Kudchodkar, Sagar B" uniqKey="Kudchodkar S" first="Sagar B" last="Kudchodkar">Sagar B. Kudchodkar</name><name sortKey="Lee, Hyojin" sort="Lee, Hyojin" uniqKey="Lee H" first="Hyojin" last="Lee">Hyojin Lee</name><name sortKey="Maslow, Joel N" sort="Maslow, Joel N" uniqKey="Maslow J" first="Joel N" last="Maslow">Joel N. Maslow</name><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><name sortKey="Park, Young K" sort="Park, Young K" uniqKey="Park Y" first="Young K" last="Park">Young K. Park</name><name sortKey="Remigio, Celine" sort="Remigio, Celine" uniqKey="Remigio C" first="Celine" last="Remigio">Celine Remigio</name></country><country name="Canada"><noRegion><name sortKey="Racine, Trina" sort="Racine, Trina" uniqKey="Racine T" first="Trina" last="Racine">Trina Racine</name></noRegion><name sortKey="Kobinger, Gary" sort="Kobinger, Gary" uniqKey="Kobinger G" first="Gary" last="Kobinger">Gary Kobinger</name><name sortKey="Lamarre, Claude" sort="Lamarre, Claude" uniqKey="Lamarre C" first="Claude" last="Lamarre">Claude Lamarre</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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